Table 3 Pros and cons of thiolated polymers
From: Modified thiomer-based nanomedicines in management of ocular complications: a review
Pros | Cons |
|---|---|
The formation of disulphide bonds is independent of ionic strength and pH | At higher pH values, the cationic thiomer chitosan exhibits precipitation |
Provide a large buffer capacity | Incompatibility with oppositely charged ionic medications |
Have exceptional qualities such as mucoadhesion, cohesiveness, and penetration | Unintentional medication release that depends on pH |
Provide options for different dose types and administration methods | Ionic repulsion causes poor cross-linking within the thiomer (in case of ionic polymer) |