Table 4 Comparison of non-thiolated and thiolated system
From: Modified thiomer-based nanomedicines in management of ocular complications: a review
(Non-Thiolated) Mucoadhesive Polymer | Thiomer |
|---|---|
Attachment by non-covalent connections to mucosal tissues | Strong covalent disulphide linkages bind the thiomer to the mucosa |
Display remarkably strong mucoadhesion | Show a remarkable increase in cohesion and adhesion (caused by intra and inter crosslinking) |
Several variables, including pH, temperature, and ions, can cause in situ gelation | The pH of the surrounding environment typically initiates the sol–gel transition |