Table 5 Polymeric drug delivery after conjugation with thiol moieties
From: Modified thiomer-based nanomedicines in management of ocular complications: a review
Charge | Polymer | Thiol moiety | Drug loaded | Route | Ref |
|---|---|---|---|---|---|
Cationic | Chitosan/Glycol chitosan | 3Mercapto-propionamide Mercaptopropionic acid TBA N-acetyl cysteine TGA TGA | Dexamethasone Ciprofloxacin Acyclovir Tobramycin Clotrimazole Calcitonin | Ocular Dermal Oral Oral Vaginal Pulmonary | [69] [70] [71] [72] [73] [74] |
Anionic | Poly (acrylic acid)/Carboxy methyl cellulose/Polycarbophil | Cysteine Cysteine Cysteine Cysteine Cysteine Cysteine and cysteamine Cysteine Cysteine Cysteine | Diclofenac Sodium Econazole & Miconazole Bromelain vit B12 Paclitaxel Nystatin Bacitracin Leu-enkephalin Heparin | Ocular Vaginal Oral Oral Oral Vaginal Oral Nasal Oral | [75] [76] [77] [78] [79] [80] [81] [82] [83] |
Non-ionic | PEG | Cysteine Mercapto-succinic acid | Cyclosporine A Pilocarpine | Ocular Ocular | [84] [85] |